The study’s authors explained: “Coupled with tectonic–geographic variations in atmospheric CO2 and enhanced continentality effect for supercontinents, Earth could reach a tipping point rendering it uninhabitable to mammalian life.”
This could then be followed by a sharp drop in temperatures, as has been documented with previous supercontinent formation, which last happened 200 million years ago.

With this sharp drop in temperatures, another extinction event, ischemic necrosis, would wipe out any humans, or other mammals, that somehow survived being blasted by 50C temperatures as CO2 flooded the atmosphere.
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